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1-(2,3,4,6-O-四苄基吡喃糖基)-三氟乙酸酯或三氯乙酸酯在无水四氯化锡存在下与一些具有代表性的硅醚保护的碱基或者含氮杂环化合物反应,合成了一系列新的苄基糖苷。对三氟乙酰氧基、三氯乙酰氧基作为新的离去基在核苷合成中的反应活性、立体选择性和反应收率进行了讨论。
1- (2,3,4,6-O-tetrabenzopyranosyl) -trifluoroacetate or trichloroacetate in the presence of anhydrous tin tetrachloride with some representative silicon ethers A series of new benzyl glycosides were synthesized by the reaction of protected bases or nitrogen-containing heterocyclic compounds. The reactivity, stereoselectivity and reaction yield of trifluoroacetoxy and trichloroacetoxy as new leaving groups in nucleoside synthesis were discussed.