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目的观察科素压、安体舒通及科素压与安体舒通联合用对大鼠心肌梗死后运动及静息心功能及心室重构的影响。方法通过建立大鼠急性心肌梗死模型,将AM I后存活的大鼠随机分为科素压组、安体舒通组、联合用药组及安慰剂组,并同时设假手术组。心肌梗死后6周,对各组大鼠进行运动及静息心功能、心室重构指标的观察。结果⑴心肌梗死后6周,安慰剂组静息心功能及运动心功能LVSP、dp/dt-、dp/dt均较假手术组降低(P<0.05),LVEDP较假手术组增高(P<0.05);科素亚组、安体舒通组及联合用药组静息心功能及运动心功能LVSP、dp/dt-、dp/dt较安慰剂组增高(P<0.05),LVEDP较安慰剂组降低(P<0.05);在联合用药组静息心功能及运动心功能LVSP、dp/dt-、dp/dt较科素亚组、安体舒通组增高(P<0.05),LVEDP降低(P<0.05)。⑵心肌梗死后6周末,安慰剂组VW/BW、LVW、LVW I及TDM均较假手术组增高(P<0.05);科素亚组、安体舒通组及联合用药组VW/BW、LVW、LVW I及TDM均较安慰剂组降低(P<0.05);联合用药组VW/BW、LVW、LVW I及TDM均较科素亚组、安体舒通组降低更显著(P<0.05)。结论科素亚、安体舒通均可通过延缓急性心肌梗死后心室重构过程,改善运动及静息心功能;二者具有协同作用。
Objective To observe the effects of kongsu pressure, spironolactone and kosin pressure and spironolactone on heart function and ventricular remodeling after myocardial infarction in rats. Methods Acute myocardial infarction (AMI) model was established in rats. The surviving AMI rats were randomly divided into two groups: kosu pressure group, spironolactone group, combination group and placebo group. Six weeks after myocardial infarction, exercise and resting heart function and ventricular remodeling were observed in each group. Results Six weeks after myocardial infarction, LVSP, dp / dt- and dp / dt of resting heart function and exercise heart function in placebo group were significantly lower than those in sham operation group and LVEDP group (P < 0.05). The LVSP, dp / dt-, dp / dt of resting and arrhythmia group were significantly higher in the combination group than those in the placeu group, spironolactone group and combination group (P <0.05) (P <0.05). LVSP, dp / dt-, dp / dt of resting heart function and exercise heart function in combination group were significantly higher than those in co-crosbos and spironolactone groups (P <0.05) (P <0.05). VW / BW, LVW, LVW I and TDM in placebo group were higher than those in sham operation group at the 6th weekend after myocardial infarction (P <0.05); VW / BW, LVW, LVW I and TDM were lower than those in placebo group (P <0.05). The VW / BW, LVW, LVW I and TDM in combination group were significantly lower than those in cortisone group and spironolactone group ). Conclusions Cosucosin and spironolactone can both improve the exercise and resting heart function by delaying the process of ventricular remodeling after acute myocardial infarction. The two drugs have synergistic effects.