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在过去几年,多发性硬化(MS)的轴突损伤引起了学者们很大的兴趣。现已证明它与活动病灶的炎症有关,但它也存在于看似正常的白质中。轴突缺损可能是MS病人持续性神经功能缺损的原因。因此,在控制疾病过程中,防止轴突损伤及促进其功能恢复是最重要的。利用现代先进的影像学技术可以发现,用某些免疫调节剂也可减少轴突损伤,但炎症期保护轴突的确切机制还不清楚。有些因素与轴突传导功能损伤有关,而有些因素直接导致轴突结构损伤,未来的目标就是干扰这些因素,防止轴突损伤。
In the past few years, multiple sclerosis (MS) axon injury caused great interest of scholars. It has been shown to be involved in the inflammation of the active lesion, but it is also present in what appears to be normal white matter. Axonal defects may be the cause of persistent neurological deficits in MS patients. Therefore, in the control of disease, to prevent axonal damage and promote their functional recovery is the most important. The use of modern advanced imaging technology can be found, with some immunomodulatory agents can reduce axonal damage, but the exact mechanism of protection of axons in the inflammatory phase is unclear. Some factors associated with axonal conduction injury, and some factors directly lead to axonal damage, the future goal is to interfere with these factors and prevent axonal injury.