1994年Zhang〔1〕等成功克隆了肥胖基因及人类的同源系列,其编码蛋白产物称为瘦素(leptin)。瘦素的发现为体内能量代谢和脂肪沉积机理的研究开辟了新的领域,引起各国学者的注意。随着研究的不断深入,发现瘦素具有更广泛的作用,在妇产科领域,瘦素与生殖、妊娠、胎儿生长发育乃至 In 1994, Zhang 〔1〕 successfully cloned obesity genes and human homologous series, which encodes the protein product called leptin (leptin). The discovery of leptin has opened up new fields for the study of energy metabolism and fat deposition mechanism in the body, arousing the attention of scholars in various countries. With the deepening of research, we found that leptin has a broader role in the field of obstetrics and gynecology, leptin and reproductive, pregnancy, fetal growth and development and even