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产妇与胎儿间 Rh 血型不合妊娠中,因非抗 D 抗体所致者正在相对增加,作者报告1例所谓 D 型不合妊娠,即母体缺乏 Rh 血型中的C-c 系和 E-e 系抗原。患者27岁,孕2产1,曾孕2个月流产1次,足月分娩1次,既往未接受过输血,非近亲婚配,因献血作抗体筛选检查发现不全抗体,并证明为 O型 D 血型。本次妊娠于孕13周5天就诊,行间接Coombs 试验为64倍,丈夫血型为 A 型 CCDee,根据遗传基因推测胎儿血型为 CDe/-D-。继续监护发现于孕34周以前抗体价保持64倍无变化,孕34周出现上升倾向,抗体价达128倍而住院。进一步做超声显象胎儿无水肿,无刺激试验(NST)亦无异常,抗体效价一直为128倍,考虑已达孕36周5天,子宫颈未成熟,准备换血用的血液也有困难,故行剖
In the case of Rh-incompatible pregnancies between maternal and fetus, the authors report a relative increase due to non-anti-D antibodies. One reported so-called D-type incompatible pregnancy, namely maternal deficiency of C-c and E-e antigens in Rh blood. The patient was 27 years old and had 2 pregnancies and 1 pregnancy. She had had a miscarriage twice in 2 months and had full-term delivery once. She had never received blood transfusion or non-relatives marriage and had not found the antibody due to blood donation screening and found to be O-D blood type. The pregnancy at 13 weeks of pregnancy 5 days of treatment, the line indirect Coombs test was 64 times, the husband’s blood type A CCDee, according to genetic speculation fetal blood type CDe / -D-. Continue to custody found that 34 weeks before the pregnancy antibody prices remained unchanged 64 times, 34 weeks of pregnancy showed an upward trend, the antibody price of 128 times and hospitalization. Further ultrasound imaging of fetal no edema, no stimulation test (NST) is no exception, the antibody titer has been 128 times, considering has reached 36 weeks of pregnancy for 5 days, the cervix is not mature, ready to exchange blood with blood is also difficult, so Line profile