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应用双抗体夹心ELISA法检测了20例流行性出血热(EHF)患者外周血清可溶性白细胞介素—2受体(SIL—2R)浓度的动态变化。结果表明EHF患者SIL—2R浓度在发热期、低血压期、少尿期及多尿期均显著高于健康对照组,并且随病情加重而明显升高.研究提示SIL—2R升高与EHF免疫病理损伤相关,动态检测SIL—2R对判定患者病情变化有一定意义。
The serum concentration of soluble interleukin-2 receptor (SIL-2R) in 20 patients with epidemic hemorrhagic fever (EHF) was measured by double antibody sandwich ELISA. The results showed that the concentration of SIL-2R in EHF patients was significantly higher than that in healthy control group during the period of fever, hypotension, oliguria and polyuria, and the SIL-2R level was significantly increased with the increase of SIL-2R. Pathological damage related to dynamic detection of SIL-2R to determine the patient’s condition has some significance.