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为了探讨天花粉及利凡诺尔引产过程中内源性前列腺素的变化,对8例羊膜腔内注射天花粉中期妊娠引产的病例及5例羊膜腔内注射利几诺尔加静滴催产素中期妊娠引产的病例,分别在用药前,用药后、流产前作血浆及羊水中前列腺素 E 与 F_(2α)(PGE 与 PGF_(2α))的放射免疫测定。天花粉引产组在用药前血浆中 PGE 为210±133微微克/毫升,PGF_(2α)为223±84微微克/毫升,用药后变化不明显;但在羊水中则变化显著,用药前 PGE 为175±74微微克/毫升,PGF_(2α)为220±80微微克/毫升,用药后则分别上升了12.8倍与23.8倍,PGF_(2α)与 PGE 的比值从1.25上升为2.33(P<0.001)。在利凡诺尔引产组中只测定羊水中前列腺素 E 及 F_(2α),测定结果为:用药前 PGE 为130±10微微克/毫升,PGF_(2α)为272±77微微克/毫升,用药后分别上升了31.1与114.9倍,PGF_(2α)与 PGE的比值从1.78上升为6.59(P<0.001)。天花粉引产组的流产时间平均为100小时,利凡诺尔引产组的流产时间平均为46小时,这可能是由于利凡诺尔破坏蜕膜的程度较严重,或由于加用了催产素以致宫缩更为强烈,导致溶酶体大量崩介,从而使前列腺素的合成与释放量远较天花粉引产组为高,故流产所需时间也短。
In order to investigate the changes of endogenous prostaglandins during induction of labor with TCS and Levanor, 8 cases of intractable amniotic injection of TCS in mid-term pregnancy and 5 cases of intra-amniotic injection of risperidone-induced intravenous oxytocin Cases, respectively, before medication, after treatment, before the abortion for plasma and amniotic fluid prostaglandin E and F_ (2α) (PGE and PGF_ (2α)) radioimmunoassay. Celastrus induction group before treatment in the plasma PGE was 210 ± 133 pg / ml, PGF2α 223 ± 84 pg / ml, no significant change after treatment; but in amniotic fluid, the change was significant before treatment PGE was 175 PGF 2α was 220 ± 80 pg / ml, and the ratio of PGF 2α and PGE increased from 1.25 to 2.33 (P <0.001) . Amniotic fluid in Richenor only prostaglandin E and F_ (2α) determination of amniotic fluid, determination results: before treatment PGE was 130 ± 10 μg / ml, PGF 2α 272 ± 77 pg / ml, medication And then increased by 31.1 and 114.9 times respectively. The ratio of PGF 2α to PGE increased from 1.78 to 6.59 (P <0.001). TCA induction of abortion time average of 100 hours, rivanol abortion group abortion time average of 46 hours, which may be due to rivanol destruction of the decidua is more serious, or due to the addition of oxytocin contractions As strong, leading to a large number of lysosomal collapse mediated, so that the synthesis and release of prostaglandin is far higher than the TCA induction group, so the time required for abortion is also short.