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目的 检测强直性脊柱炎 (AS)患者HLA B2 7抗原。方法 用特异性HLA B2 7抗血清对 3 4 8例AS患者和 72名健康者进行HLA B2 7检测。结果 3 4 8例AS中HLA B2 7阳性者 3 2 9例 ,阳性率 94.5 % ,其中弱阳性者 67例 (19.2 % ) ,多为早期患者 ;阳性者 168例 (48.3 % ) ,多为中、晚期患者 ;强阳性者 94例 (2 7.0 % ) ,亦多为中、晚期患者。早期AS患者HLA B2 7总阳性率为 91.8% ,其中以弱阳性为多 (65 .8% ) ,明显高于中、晚期患者 (P <0 .0 1) ;中期AS患者HLA B2 7总阳性率 94.9% ,其中以阳性为多 (5 5 .9% ) ,其次为强阳性 (3 2 .3 % ) ,均明显高于早期患者 (P <0 .0 1) ;晚期AS患者HLA B2 7总阳性率为 95 .7% ,中亦以阳性为多 (5 6.1% ) ,其次为强阳性 (3 2 .4% ) ,均明显高于早期患者 (P <0 .0 1) ;中、晚期AS患者的弱阳性、阳性、强阳性比较均无显著差异 (P >0 .0 5 )。 72名健康者中HLA B2 7阳性 3例 ,阳性率为 4.2 % ,其中弱阳性 2名 ,阳性 1名。结论 AS与HLA B2 7相关性强 ,HLA B2 7检测可成为诊断AS的一项指标
Objective To detect HLA B2 7 antigen in patients with ankylosing spondylitis (AS). Methods HLA B2 7 was detected in 388 AS patients and 72 healthy controls using specific HLA B2 7 antiserum. Results A total of 392 HLA-B7 positive cases were found in 388 AS patients, with a positive rate of 94.5%, of which 67 were weakly positive (19.2%), most of whom were early stage patients. 168 (48.3%) were positive, , Late patients; strong positive in 94 cases (2 7.0%), but also mostly in patients with advanced. The positive rate of HLA B2 7 in early AS patients was 91.8%, of which the weak positive (65.8%) was significantly higher than that in the middle and advanced patients (P0.01) (94.9%) were positive (55.9%), followed by strongly positive (32.3%), which were significantly higher than those in the early stage (P <0.01) The positive rate was 95.7%. The positive rate was also positive (6.11%), followed by the strong positive rate (32.4%), which were significantly higher than those in the early stage (P <0.01) Weak positive, positive, strong positive in patients with advanced AS were no significant difference (P> 0.05). Among 72 healthy persons, 3 were HLA B2 7 positive, the positive rate was 4.2%, of which 2 were weakly positive and 1 were positive. Conclusion The correlation between AS and HLA B2 7 is strong, and the detection of HLA B2 7 may be an index to diagnose AS