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There are two genotypes of the vacA intermediate region, i1 and i2; however, the association between the genotypes and gastroduodenal disease remains to be elucidated. The aim of this article was to investigate the interaction between the genotypes andH. pylori-associated diseases such as chronic gastritis, peptic ulcer disease (PUD) and gastric cancer.Methods: The meta-analysis was performed in Review Manager 4.2.2.Results: Eleven (ten articles and one abstract) met the inclusion criteria and were included. The i1 genotype increased the risk of PUD (OR = 1.70, 95% CI: 1.24-2.33,P