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利用免疫组织化学方法，研究了５１例子宫颈不典型增生（３２例轻度，１３例中度、６例重度）、５７例子宫颈炎和５１例子宫颈息肉组织石腊包埋标本中Ｐ５３的表达。结果发现：在子宫颈不典型增生、炎症、息肉组织中，Ｐ５３表达阳性者分别为Ｎ例（３１．４％）（１１例轻度、３例中度、２例重度）、３例（５３％）、３例（５．９％）。卡方检验结果，子宫颈不典型增生组织中Ｐ５３表达阳性者显著高于子宫颈炎症与息肉组织中（Ｐ＜０．００１），轻、中、重度子宫颈不黄型增生组织中Ｐ５３表达无显著差异（Ｐ＜０．０５）。结果表明；Ｐ５３基因突变是子宫颈癌发生的较早期因素，而不是癌症发生的结果；检测突变型Ｐ５３蛋白表达，对于子宫颈癌的早期诊断可能有意义。
Fifty-one cases of cervical dysplasia (32 mild, 13 moderate, 6 severe), 57 cases of cervicitis and 51 cases of cervical polyp tissue paraffin embedded specimens were examined by immunohistochemistry. The results showed that there were N cases (31.4%) in the group of cervical dysplasia, inflammation and polyps, respectively (11 mild, 3 moderate, 2 severe) and 3 %), 3 cases (5.9%). The results of Chi-square test showed that the positive expression of P53 in cervical dysplasia was significantly higher than that in cervical inflammation and polyp (P <0.001), but not in mild to moderate cervical hyperplasia Significant difference (P <0.05). The results showed that the mutation of P53 gene was the early factor of cervical cancer, not the result of cancer. Detecting the expression of mutant P53 protein may have significance for the early diagnosis of cervical cancer.