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北京大学陈鹏课题组与该校长江学者讲座教授何川课题组合作,于2013年11月3日Nature Chemical Biology在线发表论文,揭示了大肠杆菌多重抗药性调控蛋白MarR的分子机制,证明Cu2+可作为天然的信号分子(诱导剂)激活MarR蛋白并引发其介导的多重耐药性。这对于开发对抗多重抗生素耐药病菌感染的新型药物具有重要意义。该研究揭示了水杨酸以及临床广泛使用的抗生素如氨苄青霉素和诺氟沙星能够刺激大肠杆菌体内游离Cu2+浓度升高,并最终诱导MarR蛋白的去抑制。Cu2+调控MarR蛋白的分子机制为:两个相邻MarR蛋白
On April 3, 2013, Nature Chemical Biology published a paper online and revealed the molecular mechanism of Escherichia coli multi-drug resistance regulatory protein MarR. The results show that Cu2 + Activates MarR protein as a natural signaling molecule (inducer) and induces its mediated multidrug resistance. This is of great importance for the development of new drugs against multi-antibiotic-resistant bacterial infections. This study revealed that salicylic acid and clinically widely used antibiotics such as ampicillin and norfloxacin stimulate the increase of free Cu2 + concentration in E. coli and eventually induce the de-inhibition of MarR protein. The molecular mechanism by which Cu2 + regulates MarR protein is two adjacent MarR proteins