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采用溶胶–凝胶法,在不使用模板剂的情况下制备出高比表面积的介孔CaO-Al_2O_3-P_2O_5生物活性玻璃(MBGs),用BET、XRD、DTA以及FTIR对MBGs的结构进行了表征,并用生物模拟体液(SBF)在36.5℃对生物玻璃进行了体外活性测试,测试时间为1 d、3 d、7 d和14 d。介孔玻璃的比表面积最高达到461.1 m2/g,随着CaO的含量从5mol%增加到30mol%,介孔玻璃的比表面积呈降低趋势。用XRD和FTIR验证了材料的玻璃结构。然而,在生物模拟体液(SBF)实验中,当CaO摩尔含量达到20mol%时,介孔玻璃表现出较高生物活性。这种特殊的高比表面积的介孔铝磷钙生物活性玻璃在生物医药方面有潜在的应用价值。本文的实验结果对优化生物玻璃的介孔结构和CaO含量来提升玻璃的生物活性有一定的指导意义。
The mesoporous CaO-Al_2O_3-P_2O_5 bioactive glass (MBGs) with high specific surface area was prepared by sol-gel method and the structure of MBGs was characterized by BET, XRD, DTA and FTIR , And biological glass was tested for in vitro activity at 36.5 ℃ with biological simulated body fluid (SBF) for 1 d, 3 d, 7 d and 14 d. The specific surface area of mesoporous glass reaches up to 461.1 m2 / g. With the increase of CaO content from 5mol% to 30mol%, the specific surface area of mesoporous glass decreases. The glass structure of the material was verified by XRD and FTIR. However, in the biomimetic body fluid (SBF) experiment, mesoporous glass shows high biological activity when the molar content of CaO reaches 20mol%. This special high specific surface area of mesoporous aluminum phosphorus calcium bioactive glass has potential applications in biomedical applications. The experimental results in this paper have certain guiding significance for optimizing the bioactivity of glass by optimizing the mesoporous structure and CaO content of the biological glass.