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考虑到DNA及其保护剂的初级过程提出了电荷转移保护机理并用ESR等方法详细研究了若干二元混合物如胸腺嘧啶-半胶氨酸或胱氨酸,胸腺嘧喧-组氨酸或精氨酸,dTMP-咖啡酸类,DNA-咖啡酸类等。还建议了一个包括电荷转移氧化与还原在内的更普遍的纲要,如EA_(P·S)>EA_(TH)(Ⅰ);IP_(P·S)?IP_(TH)(Ⅱ)则(Ⅰ)(Ⅱ)协同保护TH。相反,如IP_(P·S)?IP_(TH)(Ⅲ),则(Ⅰ)(Ⅲ)协同敏化TH的损伤。保护与敏化的共同点是(Ⅰ),其判据为(Ⅱ)(Ⅲ)。与上述纲要相适应早已发现一个有关线性芳烃同系物分子链长与保护效应的定性规则。这些同系物可作为抑制化学致癌和保护TBP-烷烃辐解的模型化合物。同时又在详细研究了胸腺嘧啶-半胱氨酸或AET的基础上发展了氢原子转移机理,在胸腺嘧啶-半胱氨酸及胸腺嘧啶冰冻水溶液的研究中探索了胸腺嘧啶与芳香氨基酸之间的激发能转移。
Taking into account the primary process of DNA and its protective agent proposed charge transfer protection mechanism and ESR and other methods used to study a number of binary mixtures such as thymine - hemitran or cystine, thymine - histidine or ammonia Acids, dTMP-caffeic acids, DNA-caffeic acids and the like. A more generalized scheme including charge transfer oxidation and reduction is also proposed, such as EA_ (P · S)> EA_ (TH) (Ⅰ); IP_ (P · S) · IP_ (TH) Ⅰ) (Ⅱ) Collaborative protection of TH. On the contrary, (IP) (TH) (III), (I) and (III) synergistically sensitize TH injury. The common protection and sensitization are (Ⅰ), the criterion is (Ⅱ) (Ⅲ). In keeping with the above outline, a qualitative rule on the chain length and protective effect of linear aromatic hydrocarbon homologues has been found. These homologues serve as model compounds that inhibit chemical carcinogenesis and protect TBP-alkane radiolysis. At the same time, the mechanism of hydrogen atom transfer was developed on the basis of a detailed study of thymine-cysteine or AET. In the study of thymine-cysteine and thymine in aqueous solution, thymine and aromatic amino acids were explored The excitation energy transfer.