论文部分内容阅读
免疫抑制酸性蛋白(Immunosuppre-ssive Acidic protein,IAP)是松田等人在患癌的鼠血清中发现的一种蛋白,其分子量为59,000,等电点为pH3.0～3.4,含糖量约31.5％,结构类似α_1-酸性糖蛋白(α_1-AG);是一种电泳位于清蛋白区域,但又不同于α_1-AG、α_2-AT(抗凝乳蛋白酶)和清蛋白的酸性蛋白。石田认为IAP是一种调节免疫机能的因子,而松田认为来自正常人血清的1AP不具有免疫抑制活性,来自癌患者血清的IAP则有抑制植物血细胞凝集素(PHA)刺激的淋巴细胞幼稚化反应和迟发型变态反应的作用,并可促使胸腺萎缩,而来自正常人和癌患者血清中的IAP,两者在生化学和血清学上并无明显差异,但两者的免疫活性则不同。还有人认为IAP具有促进肿瘤增殖的作用。
Immunosuppression-acidic protein (IAP) is a protein found in cancer-bearing rat serum by Matsuda et al., Which has a molecular weight of 59,000, an isoelectric point of pH 3.0 to 3.4 and a sugar content of about 31.5 %, Α_1-AG glycoprotein (α_1-AG). It is an acidic protein electrophoretically located in the albumin region but different from α_1 -AG, α_2-AT (chymase) and albumin. Ishida believes that IAP is a factor that regulates immune function, whereas Matsuda believes that 1AP from normal human serum does not have immunosuppressive activity, and IAP from cancer patient serum has a phytohemagglutinin (PHA) -stimulated lymphocyte naive reaction And late-onset allergic reactions, and can promote thymic atrophy, but from the normal and cancer patients in the serum IAP, both biochemical and serological no significant difference, but both the immune activity is different. Others think that IAP has the effect of promoting tumor proliferation.