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本实验观察了预先自大鼠腹腔注射赤芍水提取液对大脑皮层缺血10min及60min时亮脑啡肽（LEK）、β－内啡肽（β－EP）、强啡肽A1－13（DynA1-13）3种阿片肽含量的影响。结果发现赤芍能抑制皮层缺血10min时LEK含量的升高，同时还能抑制皮层缺血60min时β－EP含量的升高，而对DynA1-13的含量则没有影响。因而认为赤芍治疗缺血性脑血管病的机理与其减少缺血脑组织LEK或β－EPP的释放，从而减轻缺血性脑损伤的程度有关。
In this experiment, Leucoenkephalin (LEK), β-endorphin (β-EP), and dynorphin A1-13 were preliminarily used to inject intraperitoneal injection of Radix Paeoniae Radix extract to rat cerebral cortex during 10 min and 60 min ischemia. DynA1-13) Effects of three opioid peptide contents. The results showed that red peony could inhibit the increase of LEK content during cortical ischemia at 10 min, and also inhibited the increase of β-EP content during cortex ischemia at 60 min, but had no effect on the content of DynA1-13. Therefore, it is believed that the mechanism of red peony treatment of ischemic cerebrovascular disease is related to the reduction of the release of LEK or β-EPP in ischemic brain tissue, and thus reduce the degree of ischemic brain injury.