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目的 :研究胃癌根治术后行早期肠内营养患者配合相关耳—体穴针刺对机体免疫功能的影响。方法 :3 2例胃癌根治术患者均予等氮、等热量早期肠内营养 8天 (能全力 ,Nutricia提供 ) ,随机分为 2组 ,研究组 (n=16)同时配合相关耳—体穴针刺。两组患者手术前后均定期监测肝功能各项指标、外周血 T细胞亚群、免疫球蛋白、急性炎性反应指标及胃肠道功能恢复时间、并发症发生情况。结果 :两组均无手术并发症及营养支持代谢并发症发生。手术前后 AST、ACT、TBIL、AKP均无升高 ;与术前 (POD0 )比较 ,术后第 1天 (POD1)两组血浆白蛋白均明显下降 (P<0 .0 1) ,外周血 T细胞亚群CD4、CD4/ CD8及血浆球蛋白 Ig G、Ig M、Ig A均明显下降 (P<0 .0 1及 P<0 .0 5) ,而血浆急性炎性反应指标 (IL-6、PGE2 )均显著升高 (P<0 .0 1) ;至 POD8两组血浆白蛋白、外周血 T细胞亚群 CD4、CD4/CD8及血浆球蛋白 Ig G均有提高 ,与对照组比较 ,研究组升高更明显 (P<0 .0 5) ,而急性炎性反应指标 (IL-6、PGE2 )均有所下降 ,研究组下降更明显 (P<0 .0 5) ,同时 ,研究组肠功能恢复较快 ,对早期肠内喂养耐受性好。结论 :对胃癌根治术后行早期肠内喂养的患者予配合相关耳—体穴针刺 ,可有效地刺激机体免疫功能 ,缓解过度的急性炎性反应 ,促进?
Objective: To study the effect of acupuncture on the immune function of patients with early enteral nutrition after radical gastrectomy. Methods: All 32 patients undergoing radical gastrectomy were given equal nitrogen and early heat for enteral nutrition for 8 days (provided by Nutricia) and randomly divided into two groups. The study group (n = 16) acupuncture. The two groups of patients before and after regular monitoring of liver function indicators, peripheral blood T cell subsets, immunoglobulin, acute inflammatory response indicators and gastrointestinal function recovery time, complications. Results: There was no operative complications and nutritional support for metabolic complications in both groups. AST, ACT, TBIL and AKP did not increase before and after operation. Compared with preoperative (POD0), serum albumin of the first day postoperatively (POD1) decreased significantly (P <0.01), peripheral blood T CD4, CD4 / CD8 and plasma globulin Ig G, Ig M and Ig A were significantly decreased (P <0.01 and P <0.05, respectively), while plasma levels of IL-6 (P <0.01). The levels of CD4, CD4 / CD8 and plasma globulin Ig G of plasma albumin and peripheral blood T cells in POD8 group were significantly increased compared with those in control group The study group increased more significantly (P <0.05), while acute inflammatory response index (IL-6, PGE2) decreased, the study group decreased more significantly (P <0.05), while the study Group intestinal function recovery faster, good early enteral feeding tolerance. CONCLUSION: Acupuncture at the ear-body acupoint with early enteral feeding after radical gastrectomy can effectively stimulate the body’s immune function, relieve the excessive acute inflammatory reaction and promote the development of gastric cancer.