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血栓性血小板减少性紫癜(简称 TTP)的病因以及血管病变的发病原因尚未明瞭。一些最近的研究结果对玻璃样微血栓的本质和这种病的病理学特点提出了新的线索。现在人们对于广泛的微血栓形成决定临床表现的严重性和预后这一看法已经基本赞同,广泛的微血栓实际上累及各个脏器而造成种种症状,而血液学的改变如伴有周围血中出现红细胞碎片的溶血,以及血小板减少和凝血异常,都可以用闭塞性微血栓病变来解释。尽管如此,至今尚不能回答导致微血栓形成的主要病因。本文着重综述血小板和纤维蛋白溶解在 TTP 血栓形成中的作用。
Thrombotic thrombocytopenic purpura (referred to as TTP) and the etiology of the pathogenesis of vascular disease is unclear. Some recent findings provide new clues to the nature of glass-like microthrombi and the pathological features of the disease. It is now generally agreed that extensive microthrombi formation determines the severity and prognosis of clinical manifestations. Extensive microthrombi actually affect various organs and cause various symptoms. Changes in hematology, such as those associated with the presence of peripheral blood Hemolysis of red blood cell fragments, and thrombocytopenia and coagulation abnormalities, can be used to explain the occlusive micro-thrombus lesions. However, so far, can not answer the main cause of micro-thrombosis. This article highlights the role of platelets and fibrinolysis in TTP thrombosis.