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目的:探讨双歧四联活菌辅助草酸艾司西酞普兰治疗抑郁症患者的临床疗效及其可能作用机制，为进一步临床研究提供依据。方法:选取台州市第二人民医院2019年9月至2021年3月收治的抑郁症患者100例为观察对象，采用随机数字表法分为对照组和观察组，每组50例。对照组采用草酸艾司西酞普兰和安慰剂治疗，观察组采用草酸艾司西酞普兰联合双歧四联活菌治疗，两组治疗周期为9周。采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）对两组患者治疗前后心理状态进行评分，应用酶联免疫吸附法测定两组患者治疗前后血清皮质醇、炎性因子［白细胞介素1β（IL-1β）、肿瘤坏死因子（TNF-α）］水平。结果:治疗后，两组心理状况评分均较治疗前显著下降，观察组HAMD评分［（10.78±2.03）分］、HAMA评分［（6.37±2.58）分］均显著低于对照组［（16.78±2.85）分、（13.23±2.95）分］（n t=11.40、13.38，均n P < 0.001）。治疗后，两组血清皮质醇、IL-1β、TNF-α水平均较治疗前显著下降，观察组血清皮质醇［（137.34±63.29）μg/L］、IL-1β［（14.38±6.08）ng/L］、TNF-α［（13.95±6.46）ng/L］均显著低于对照组［（181.22±59.27）μg/L、（25.94±6.92）ng/L、（20.44±6.24）ng/L］（ n t=15.29、6.16、9.24，均n P < 0.001）。n 结论:采用双歧四联活菌辅助草酸艾司西酞普兰治疗抑郁症可有效减轻患者抑郁、焦虑情绪，显著降低血清皮质醇及IL-1β、TNF-α水平。“,”Objective:To investigate the clinical efficacy and possible mechanism of bifidobacterium tetralogy combined with escitalopram oxalate in the treatment of patients with depression and to provide evidence for further clinical research.Methods:A total of 100 patients with depression who received treatment in Taizhou Second People\'s Hospital from September 2019 to March 2021 were included in this study. They were randomly assigned to receive either escitalopram oxalate and placebo (control group, n n = 50) or escitalopram oxalate and bifidobacterium tetralogy (observation group, n n = 50). All patients received 9 weeks of treatment. Psychological status pre- and post-treatment was evaluated using the Hamilton Rating Scale for Depression and the Hamilton Rating Scale for Anxiety. Serum cortisol, inflammatory factors interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels were detected using the enzyme-linked immunosorbent assay.n Results:Physiological status scores in each group were significantly lower after treatment compared with before treatment. Scores of the Hamilton Rating Scale for Depression and the Hamilton Rating Scale for Anxiety scores post-treatment in the observation group were (10.78 ± 2.03) points and (6.37 ± 2.58) points, which were significantly lower than those in the control group [(16.78 ± 2.85) points, (13.23 ± 2.95) points, n t = 11.40, 13.38, both n P < 0.001]. Serum levels of cortisol, inflammatory factors IL-1β and TNF-α in each group were significantly decreased after treatment compared with before treatment. Serum levels of cortisol, inflammatory factors IL-1β and TNF-α post-treatment in the observation group were (137.34 ± 63.29) μg/L, (14.38 ± 6.08)ng/L, (13.95 ± 6.46) ng/L, which were significantly lower than those in the control group [(181.22 ± 59.27) μg/L, (25.94 ± 6.92) ng/L, (20.44 ± 6.24) ng/L, n t = 15.29, 6.16, 9.24, all n P < 0.001).n Conclusion:Bifidobacterium tetralogy combined with escitalopram oxalate is highly effective on depression. The combined therapy can remarkably reduce depression and anxiety symptoms and greatly decrease serum cortisol, IL-1β, and TNF-α levels.