论文部分内容阅读
一、催产素的发现、分离和生理作用1895年 Oliver 和 Schaffer 发现,动物垂体后叶(posterior pituitary)的提取物可使哺乳动物的血压增加;1906年 Dale 确认垂体后叶的粗提取物能使兔的子宫收缩,于是引起人们对这个化合物的注意。以后又陆续发现了它的其它生理效应,例如诱导分娩、排乳以及抑制排尿等;其中某些效应多年来已应用到临床医学上,如催产效应的应用于产科,及制尿作用的应用于控制糖尿病人的尿崩症等。从本世纪初期以来,有不少人企图分离出纯粹的垂体后叶要素,但很不容易达到目的,因为体腺中的有效要素非常少,又很不稳定。1928年 Kamm 和 Grote
Oxytocin Discovery, Separation, and Physiological Effects Oliver and Schaffer (1895) found that the extract of the posterior pituitary of an animal increases the blood pressure in mammals; in 1906 Dale confirmed that the crude extract of the posterior pituitary gland enabled Rabbit’s uterus contracted, thus arousing people’s attention to this compound. Later, one after another found its other physiological effects, such as induction of labor, breast milk and inhibit urination, etc .; some of which have been applied to clinical medicine over the years, such as the role of oxytocin in obstetrics, and the role of urine in the application Diabetes control diabetes insipidus. Since the beginning of this century, many people have tried to separate the pure elements of the posterior pituitary gland, but it is not easy to achieve the goal because of the very few effective elements in the gland and the instability. 1928 Kamm and Grote