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将鼻咽癌单克隆细胞株ＣＮＥ－２Ｚ－Ｈ５移植于裸鼠，待移植瘤发生转移后，取其淋巴结和肺转移灶癌组织移植裸鼠，如此重复２～４个循环后，观察每代移植瘤的转移表型及肿瘤细胞ｃ－ｍｙｃ、ｃ－ｆｏｓ、ｂｃｌ－２癌基因蛋白的表达。结果表明：随着肿瘤细胞的演进，每代移植瘤的转移率增高，且转移途径更为单一；肿瘤细胞ｃ－ｍｙｃ、ｂｃｌ－２癌基因蛋白的表达增强；ｃ－ｆｏｓ癌基因蛋白的表达降低。提示：肿瘤细胞的演进、转移及癌基因蛋白的表达存在一定的关系。
The nasopharyngeal carcinoma monoclonal cell line CNE-2Z-H5 was transplanted into nude mice. After the tumors had metastasized, their lymph nodes and lung metastases were transplanted into nude mice. After repeated 2 to 4 cycles, each generation was observed. The metastatic phenotype of transplanted tumors and the expression of c-myc, c-fos and bcl-2 oncogene proteins in tumor cells. The results showed that with the evolution of tumor cells, the metastasis rate of each transplanted tumor increased, and the transfer pathway was more uniform; the expression of c-myc and bcl-2 oncogene proteins was enhanced; the expression of c-fos oncogene protein reduce. Tip: There is a certain relationship between the evolution and metastasis of tumor cells and the expression of oncoproteins.