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目的探讨10种肿瘤标志物检测在肝癌诊断中的应用价值。方法选择肝癌患者40例作为观察组(肝癌组),以同期住院非肿癌患者30例作为对照(对照组),同期同法检测10种肿瘤标志物,将两组阳性率及检测值进行对比。结果AFP、CA-199、Ferr、CA-125、CEA在肝癌组阳性率分别为52.9%、25.7%、21.4%、12.9%及7.1%;对照组则分别为22.9%、10.0%、7.1%、8.6%及10.0%。两组比较检测值AFP、CA-199及Ferr显示肝癌组均高于对照组,差异有统计学意义(P<0.05)。AFP+CA-199、AFP+Ferr、AFP+CA-125联合阳性率肝癌组可达55.7%;AFP+CA-199+CA-125、AFP+CA-199+CEA、AFP+Ferr+CA-125肝癌组阳性率可达57.1%。结论肿瘤标志物检测对肝癌的诊断有一定的价值,联合检测可适度提高诊断阳性率。
Objective To investigate the diagnostic value of 10 tumor markers in the diagnosis of liver cancer. Methods Forty patients with hepatocellular carcinoma (HCC) were selected as the observation group (HCC group) and 30 patients with non-cancerous inpatients as control group (control group). Ten tumor markers were detected by the same method in the same period. The positive rate and the detection value were compared . Results The positive rates of AFP, CA-199, Ferr, CA-125 and CEA in hepatocellular carcinoma were 52.9%, 25.7%, 21.4%, 12.9% and 7.1% respectively, while those in control group were 22.9%, 10.0% and 7.1% 8.6% and 10.0%. Compared with the control group, the levels of AFP, CA-199 and Ferr in the two groups were significantly higher than those in the control group (P <0.05). The positive rate of AFP + CA-199, AFP + Ferr and AFP + CA-125 in hepatocellular carcinoma group was 55.7%, AFP + CA-199 + CA-125, AFP + CA- 199 + CEA, AFP + Ferr + CA-125 The positive rate of liver cancer group reached 57.1%. Conclusion The detection of tumor markers has a certain value in the diagnosis of liver cancer. Combined detection can moderately increase the diagnostic positive rate.