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目的：探讨系统性护理干预在预防硬膜外置管相关性感染中的作用，为临床降低硬膜外置管相关性感染提供依据。方法选择2012年3月－2013年4月接受硬膜外腔置管治疗的颈、腰椎间盘突出症患者139例，设为观察组；另选择2010年7月－2012年2月硬膜外腔置管治疗的颈、腰椎间盘突出症患者139例作为对照组，两组患者均行硬膜外腔置管、神经阻滞治疗，观察组采用系统性护理干预，而对照组采用常规护理，对比观察两组各部位细菌培养结果和硬膜外置管相关性感染率。结果观察组硬膜外导管尖端、剩余药液和管周皮肤病原菌培养阳性例数分别为1、3例和3例，阳性率分别为0．72％、2．16％和2．16％，均低于对照组的3．60％、5．04％和10．07％，其中管周皮肤病原菌培养阳性率两组间比较差异有统计学意义（ P＜0．05）；硬膜外置管相关性感染观察组发生1例，感染率为0．72％，对照组共发生8例，感染率为5．76％，两组感染率比较差异有统计学意义（ P＜0．05）。结论硬膜外置管相关性感染不容忽视，导管病原菌阳性是置管相关性感染的病源，系统性护理干预可有效预防硬膜外置管相关性感染的发生。“,”OBJECTIVE To explore the effect of systemic nursing intervention on prevention of epidural catheter related infections ,in order to provide the basis to reduce epidural catheter related infections in clinic .METHODS Totally 139 patients with cervical ,lumbar intervertebral disc protrusion in our hospital from Mar .2012 - Apr . 2013 were enrolled and set as the observation group ,besides ,another 139 patients with the same disease in our hospital from Jul .2010 - Feb .2012 were enrolled as the control group .All patients in two groups received epidural catheter treatment and nerve block .The observation group used systemic nursing intervention ,while the control group used conventional care . The bacterial specimens from epidural catheter and the rate of epidural catheter related infections in two groups were compared .RESULTS The number of positive cases of bacterial culture for the catheter tip ,the residual medicine liquid and the pipe periderm skin were respectively 1 ,3 ,and 3 in observation group ,the positive rate was respectively 0 .72% ,2 .16% and 2 .16% ,which were lower than the control group whose positive rate was respectively 3 .60% ,5 .04% ,10 .07% .There was significant difference in the positive rate for the tube periderm skin bacteria culture between the two groups (P<0 .05) .There was 1 case of epidural catheter related infections in the observation group ,with the infection rate of 0 .72% ,while 8 cases in the control group (0 .72% ) .There was significant difference between the two groups (P<0 .05) .CONCLUSIONS Epidural catheter related infections should not be ignored ,positive catheter bacteria are the sources of catheter related infections .Systemic nursing intervention can effectively prevent the occurrence of epidural catheter related infections .