目的总结糖尿病足溃疡患者耐甲氧西林金黄色葡萄球菌(MRSA)感染致骨髓炎临床特征,并与甲氧西林敏感金黄色葡萄球菌(MSSA)感染患者进行对比。方法调查2007年1月-2011年3月187例糖尿病足溃疡金黄色葡萄球菌感染致骨髓炎患者临床资料,所有患者入院后即行手术治疗,根据细菌培养结果将患者分为MRSA感染组84例及MSSA感染组103例,比较两组患者的临床治疗效果及预后。结果入院时MRSA组患者体温、白细胞计数、组织坏死及恶臭发生率较重,分别为(37.8±8.1)℃、(11.9±2.2)×109/L、56.0%、54.8%,MSSA分别为(36.2±7.3)℃、(6.7±1.2)×109/L、20.4%、17.5%,两组比较差异有统计学意义(P<0.05);MRSA组患者接受手术次数为(2.6±0.6)次多于MSSA组患者的(1.2±0.3)次,差异有统计学意义(P<0.05);MRSA和MSSA组患者肢体保留率分别为79.8%和78.6%,差异无统计学意义。结论在给予及时、有效治疗的情况下,糖尿病足感染MRSA致骨髓炎其预后与MSSA感染患者类似。 Objective To summarize the clinical features of osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) infection in patients with diabetic foot ulcer and compare it with that of methicillin-sensitive Staphylococcus aureus (MSSA). Methods The clinical data of 187 patients with osteomyelitis caused by Staphylococcus aureus in diabetic foot ulcer from January 2007 to March 2011 were collected. All patients were surgically treated after admission. According to the results of bacterial culture, 84 patients were divided into MRSA infection group and 103 cases of MSSA infection group, the clinical efficacy and prognosis of two groups were compared. Results The incidences of body temperature, white blood cell count, tissue necrosis and malodour in patients with MRSA at admission were (37.8 ± 8.1) ℃, (11.9 ± 2.2) × 109 / L, 56.0% and 54.8%, respectively (6.7 ± 1.2) × 109 / L, 20.4% and 17.5%, respectively. The difference between the two groups was statistically significant (P <0.05). The number of operation in MRSA group was (2.6 ± 0.6) more than that in MRSA group (1.2 ± 0.3) times in MSSA group, the difference was statistically significant (P <0.05). The retention rates of limbs in patients with MSSA and MSSA were 79.8% and 78.6%, respectively, with no significant difference. Conclusions In the case of timely and effective treatment, the prognosis of MRSA-induced osteomyelitis of diabetic foot is similar to that of MSSA.