UCP2蛋白通过调节细胞内ROS对上皮性卵巢癌的耐药性产生影响

来源 :湖北民族大学学报:医学版 | 被引量 : 0次 | 上传用户：rookielv

【摘要】

：

目的使用解偶联蛋白2(UCP2)抑制剂京尼平抑制UCP2功能,解偶联剂羰基-氰-对-三氟甲氧基苯腙(FCCP)模拟UCP2的解偶联作用,研究UCP2、活性氧(ROS)水平和人卵巢癌细胞顺铂(DDP)耐药性之间的关系。方法COC1/DDP细胞分为空白组、FCCP组、京尼平组、DDP组、DDP联合FCCP组和DDP联合京尼平组,测定各组细胞的凋亡率和ROS产量,使用SPSS 19.0进行独立样本t检验。结果在不同浓度的顺铂联合用药条件下,京尼平表现为促进细胞凋亡(P<0.05),FCCP则显著抑制细胞凋

【作者】

：

魏冬梅邹娟梅玲

【机构】

：

四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室,四川大学华西第二医院妇科,四川大学华西第二医院病理科

【出处】

：

湖北民族大学学报:医学版

【发表日期】

：

2021年3期

【关键词】

：

上皮性卵巢癌解偶联蛋白2 活性氧顺铂耐药性

【基金项目】

：

四川省卫生和计划生育委员会普及应用项目(17PJ243)。

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UCP2蛋白通过调节细胞内ROS对上皮性卵巢癌的耐药性产生影响

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