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目的:观察地塞米松对海水淹溺性肺水肿兔的动脉血氧分压(PaO2)及肺水肿的影响。方法:24只兔随机分成对照组和地塞米松治疗组,每组各12只。制备海水淹溺性肺水肿机械通气模型后,地塞米松治疗组在海水灌注20 min后经颈动脉注射地塞米松(1 mg/kg),对照组则注入2 ml生理盐水。观察海水灌注前即刻、海水灌注后20 min和180 min的PaO2、PaCO2、胸肺静态顺应性(CT)、动态顺应性(CD),并检测血管外肺水含量指数(EVLWI)及伊文思兰漏出指数(ELI)。结果:两组海水灌注前即刻和海水灌注后20 min的PaO2、PaCO2、CT及CD均无统计学差异,但海水灌注后180 min地塞米松治疗组的PaO2、CT及CD均显著高于对照组,而PaCO2显著低于对照组(P<0.05)。地塞米松治疗组的EVLWI和ELI均低于对照组(P<0.05)。结论:地塞米松可改善海水淹溺性肺水肿兔的缺氧及减轻肺水肿。
Objective: To observe the effects of dexamethasone on arterial partial pressure of oxygen (PaO2) and pulmonary edema in rabbits with submerged pulmonary edema in seawater. Methods: Twenty-four rabbits were randomly divided into control group and dexamethasone treatment group, 12 rats in each group. Dexamethasone treatment group was injected with dexamethasone (1 mg / kg) via the carotid artery 20 min after seawater infusion and 2 ml normal saline in the control group after preparation of the mechanical ventilation model of drowning pulmonary edema in seawater. The PaO2, PaCO2, CT, CD, and extravascular lung water content index (EVLWI) of 20 min and 180 min after seawater perfusion were observed immediately before seawater perfusion. Leakage index (ELI). Results: There were no significant differences in PaO2, PaCO2, CT and CD immediately before and immediately after seawater perfusion in both groups, but PaO2, CT and CD in 180 min dexamethasone group after seawater perfusion were significantly higher than those in control group Group, while PaCO2 was significantly lower than the control group (P <0.05). Dexamethasone treatment group EVLWI and ELI were lower than the control group (P <0.05). Conclusion: Dexamethasone can improve hypoxia and reduce pulmonary edema in rabbits with drowning pulmonary edema in seawater.