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背景 目前胰腺癌的预后仍然很差,总体5年生存率仅5％～20％,主要原因在于胰腺癌早期即有肿瘤细胞经淋巴、血液播散,从而导致远处转移、局部复发及腹腔种植等。常用的肿瘤分期法并没有将这些播散的肿瘤细胞包括在内,故往往低估了病情。近年来,有关肿瘤特异性抗原和组织特异性标志物的研究有不少进展,除对淋巴结进行常规的组织病理学检查外,还分析、检测骨髓、血液、腹腔灌洗液中可能存在的肿瘤细胞,这些结果可能对肿瘤分期及胰腺癌病人的预后产生影响。
Background At present, the prognosis of pancreatic cancer is still very poor. The overall 5-year survival rate is only 5% -20%. The main reason is that pancreatic cancer is disseminated by lymphatic and blood cells in the early stage, leading to distant metastasis, local recurrence and peritoneal implantation Wait. Commonly used tumor staging does not include these spread of tumor cells, it is often underestimated the disease. In recent years, there have been many advances in the study of tumor-specific antigens and tissue-specific markers. In addition to performing routine histopathological examination of lymph nodes, tumors in the bone marrow, blood and peritoneal lavage fluids can be analyzed and detected Cells, these results may affect the tumor staging and prognosis of patients with pancreatic cancer.