脂联素(Adiponectin,APN)是近年来发现的一种由脂肪组织分泌的由244个氨基酸组成的蛋白质类激素,在血液中以二聚体、六聚体和多聚体(HWM)形式存在〔1,2〕,具有调节胰岛素敏感性、抗炎和抗动脉粥样硬化的重要作用。已发现两种脂联素受体在体内广泛分布,AdipoR1主要分布在骨骼肌,AdipoR2主要分布在肝脏。由于脂联素是调节胰岛素和糖代谢的关键因子,而胎儿的生长发育受胰岛素和糖代谢的影响,因此,脂联素可能是调节胎儿宫内发育的候选因子之一〔3〕。现就脐血脂联素相关因素的研究进展综述如下: Adiponectin (APN) is a 244-amino acid protein hormone secreted by adipose tissue in recent years and exists in blood as dimer, hexamer and multimer (HWM) 〔1,2〕, with the regulation of insulin sensitivity, anti-inflammatory and anti-atherosclerotic important role. Two adiponectin receptors have been found widely distributed in the body, AdipoR1 mainly in skeletal muscle, and AdipoR2 mainly in the liver. Because adiponectin is a key factor regulating insulin and glucose metabolism, and fetal growth and development by insulin and glucose metabolism, therefore, adiponectin may be one of the factors that regulate fetal development [3]. Now on the umbilical blood adiponectin related factors are summarized as follows: