子宫内膜癌是最常见 的妇科恶性肿瘤之一,近年来其遗传学方面的研究日益受到关注。遗传性子宫内膜癌是Lynch Ⅱ综合征最常见的肠道外表现。与散发型相比,其在特异性家族中发病率高,发病年龄低。在分子生物学方面,已发现了多种与之相关的基因。在有肿瘤遗传倾向的家系中,应对其家族成员加强监控,并寻找特异性遗传标记物,以发现高危人群。 Endometrial cancer is one of the most common gynecological malignancies. In recent years, its genetics research has drawn more and more attention. Hereditary endometrial cancer is the most common form of parenteral Lynch syndrome. Compared with the sporadic, its incidence in the specific family incidence, age of onset is low. In molecular biology, a number of genes have been discovered. In pedigrees with genetic predisposition to tumors, surveillance should be stepped-up to their family members and specific genetic markers should be sought to identify at-risk populations.