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目的探讨慢性阻塞性肺病(COPD)患者呼吸肌力恢复同维生素C、E及血清瘦素的关系。方法将45例病情稳定的COPD患者随机分为维生素治疗组25例和呼吸康复训练组20例,常规药物治疗基础上,维生素组每日于饮食中适量添加维生素C、E。另外选择20例健康志愿者作为对照组,经30d治疗后分别测定各组维生素C、E,肺通气功能、呼吸肌力、呼吸中枢驱动功能等指标。结果治疗前患者组的维生素C、E水平显著低于对照组。治疗后,维生素组呼吸肌力相比康复训练组恢复佳,维生素C、E水平显著高于康复训练组(P<0.05)。此外,血清瘦素与最大吸气压正相关(r=0.153)。结论血清维生素C、E同COPD患者呼吸肌力恢复相关,提高患者的维生素C、E水平可加速COPD患者呼吸肌力恢复,血清瘦素同呼吸肌力也具有一定相关性。
Objective To investigate the relationship between respiratory muscle strength recovery and vitamin C, E and serum leptin in patients with chronic obstructive pulmonary disease (COPD). Methods Forty-five COPD patients with stable disease were randomly divided into vitamin therapy group (n = 25) and respiratory rehabilitation training group (n = 20). On the basis of routine drug therapy, vitamin C and vitamin E were added to the diet daily. In addition, 20 healthy volunteers were selected as the control group. After 30 days of treatment, the indexes of vitamin C, E, pulmonary ventilation, respiratory muscle strength and respiratory center drive were determined. Results The levels of vitamin C and E in patients before treatment were significantly lower than those in the control group. After treatment, respiration muscle strength of vitamin group was better than that of rehabilitation training group, and vitamin C and E levels were significantly higher than that of rehabilitation training group (P <0.05). In addition, serum leptin positively correlated with maximum inspiratory pressure (r = 0.153). Conclusions Serum vitamin C and vitamin E are related to resuscitation of respiratory muscle in patients with COPD. Increasing vitamin C and E levels in patients with chronic obstructive pulmonary disease can accelerate the recovery of respiratory muscle strength in COPD patients. Serum leptin also has some correlation with respiration muscle strength.