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作者列举充分的材料证明,前列腺素(PG)与癌肿的骨髓转移有关,并推测PG可能涉及癌肿的播散。从82例妇女手术切除得到的乳腺肿块标本作病理检查,并从肿块中取出部分组织作PG研究。病理检查证实66例为乳腺癌,16例为良性肿瘤。从23个乳腺肿块中获得肉眼正常的乳腺组织标本。所有标本切成5～15毫克的小垆,在室温条件下用蚁酸酸化至pH3的Kreb’s溶液乙醇混合液(1/1)中制成匀浆,以测PG样物质的基础量,或在Kreb’s溶液中通入含5%CO_2的氧气,以便制成匀浆时组织仍能合成PG。在Kreb’s溶液的匀浆中抽提出的PG样物质的含量为总量,总量减去基础量为合成量。结果以PGE_2的毫微克当量/克新鲜组织来表示。所有恶性肿瘤的患者,术前和术后立即从静脉注射~(99)锝标记的乙烷羟基双磷
The authors cited sufficient materials to prove that prostaglandin (PG) is related to the bone marrow metastasis of cancer, and speculated that PG may involve the spread of cancer. Mammary gland specimens obtained from surgical resection of 82 women were used for pathological examination, and some tissues were removed from the tumor for PG study. Pathological examination confirmed 66 cases of breast cancer, 16 cases of benign tumors. Normal human breast tissue specimens were obtained from 23 breast masses. All specimens were cut into 5 to 15 milligrams of small bismuth and homogenized in an ethanol mixture (1/1) of Kreb’s solution acidified to pH 3 with formic acid at room temperature to measure the base amount of PG-like material, or Kreb’s solution is filled with oxygen containing 5% CO2 so that the tissue can still synthesize PG when homogenized. The content of the PG-like substance extracted in the homogenate of the Kreb’s solution is the total amount, and the total amount minus the basic amount is the total amount. The results are expressed in picogram equivalents per gram fresh tissue of PGE2. In all patients with malignant tumors, intravenous (99) hydrazine-labeled ethane-dihydroxy phosphorus was injected preoperatively and immediately after surgery.