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以往,肺小细胞癌的治疗,不论用外科切除或照射均未奏效,因为此型肺癌易转移扩散。单纯采用化疗,患者生存期也不长,因为化疗还不能有效地控制大面积受累部位的病变。脑转移后,化疗更不易见效。因此,作者试用大剂量化疗+放疗,同时加上预防性全脑照射的综合治疗方法。接受治疗的21名患者,均经活检确诊。10例入院时已有胸外转移,11例无胸外转移但局部侵犯广泛,并有局部淋巴结转移,均不能手术,所有的患者均接受过其他治疗。化疗采用周期性静脉注射,阿霉素(40毫克/平方米)、长春新碱(2毫
In the past, the treatment of small cell lung cancer has not been effective regardless of surgical resection or irradiation, because this type of lung cancer is easy to metastasize and spread. With chemotherapy alone, the survival of patients is not long, because chemotherapy can not effectively control the lesions in the affected area. After brain metastases, chemotherapy is less effective. Therefore, the authors tried high-dose chemotherapy + radiotherapy, combined with a comprehensive treatment of preventive whole brain irradiation. Twenty-one patients who were treated were confirmed by biopsy. 10 cases had chest metastasis at the time of admission, 11 cases had no chest metastasis but extensive local invasion, and there was local lymph node metastasis. All patients were inoperable. All patients received other treatments. Chemotherapy with periodic intravenous injections, doxorubicin (40 mg/m2), vincristine (2 mM)