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目的探讨碳酸酐酶Ⅸ(CAⅨ)和半乳糖凝集素3(Galectin-3)在结肠腺癌发生、发展中的作用。方法采用免疫组化SP法检测86份结肠腺癌组织(结肠癌组)、20份结肠管状腺瘤组织(腺瘤组)及20份正常结肠组织(正常组)中CAⅨ和Galectin-3表达,分析其表达与结肠腺癌临床病理特征的关系。结果各组CAⅨ和Galectin-3均有表达,结肠癌组CAⅨ和Galectin-3阳性率均显著高于正常组及腺瘤组(P均<0.05);Galectin-3、CAⅨ阳性表达与结肠腺癌肿瘤体积、淋巴结转移相关(P<0.05),与结肠腺癌患者性别、年龄无相关关系。结论 CAⅨ、Galec-tin-3在结肠腺癌组织中高表达,其可能是结肠腺癌发展的相关因子;CAⅨ、Galectin-3表达可作为预测结肠腺癌浸润、转移和预后的重要指标。
Objective To investigate the role of carbonic anhydrase IX (CAIX) and galectin-3 in the development and progression of colon adenocarcinoma. Methods The expressions of CAⅨ and Galectin-3 in 86 colon adenocarcinoma (colon cancer), 20 colon adenoma (adenoma) and 20 normal colon (normal) tissues were detected by immunohistochemical SP method. The relationship between the expression and clinical and pathological features of colon adenocarcinoma was analyzed. Results The positive rates of CAⅨ and Galectin-3 in colon cancer group were significantly higher than those in normal group and adenoma group (all P <0.05). The positive expressions of Galectin-3, CAⅨ and colon adenocarcinoma Tumor volume and lymph node metastasis (P <0.05), but not with the gender and age of patients with colon adenocarcinoma. Conclusions CAⅨ and Galec-tin-3 are overexpressed in colon adenocarcinoma and may play an important role in the development of colon adenocarcinoma. Expression of CAⅨ and Galectin-3 may serve as an important index for predicting the invasion, metastasis and prognosis of colon adenocarcinoma.