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目的了解新疆地区Kaposi肉瘤(Kaposi’s sarcoma,KS)患者的临床特征,探讨最佳治疗方案及其转归的影响因素。方法回顾性分析本院2002年3月-2016年6月诊治的59例KS患者临床资料。结果59例KS患者中,36例经典型KS,22例艾滋病相关型卡波西肉瘤(AIDS-KS),1例医源性KS。以维吾尔族男性为主,与AIDS-KS患者相比,经典型KS患者发病年龄及病程更长,皮损多局限于四肢远端,少见于头面部、躯干及口腔黏膜,少有浅表淋巴结肿大及内脏器官受累。经典型KS患者以放疗及系统免疫治疗为主,AIDS-KS应积极进行高效抗反转录病毒治疗(HAART),必要时可行联合放疗,疗效较好。结论新疆地区经典型KS与AIDS-KS患者临床特征及治疗转归明显不同,KS多见于维吾尔族,经典型KS皮损以四肢远端受累为主,很少累及内脏器官,病变呈相对良性的过程,大多数患者对局部放疗或系统药物治疗有效。AIDS-KS皮损广泛,易累及内脏器官,预后较经典型KS差。
Objective To investigate the clinical features of Kaposi’s sarcoma (KS) patients in Xinjiang and to explore the best treatment and the influencing factors of Kaposi’s sarcoma (KS). Methods The clinical data of 59 patients with KS treated in our hospital from March 2002 to June 2016 were retrospectively analyzed. Results Of the 59 patients with KS, 36 were classic KS, 22 AIDS-related AIDS-KS and 1 iatrogenic KS. Compared with AIDS-KS patients, the age and course of the disease in classic KS patients are longer than that in AIDS-KS patients. The skin lesions are mostly confined to the distal extremities and are rare in the head and face, trunk and oral mucosa, with few superficial lymph nodes Swollen and visceral organs involved. Classical KS patients with radiation therapy and systemic immunotherapy, AIDS-KS should actively carry out highly effective anti-retroviral therapy (HAART), if feasible, combined radiotherapy, the better effect. Conclusion The clinical features and treatment outcomes of classic KS and AIDS-KS patients in Xinjiang are obviously different. KS is more common in Uygur people. The classic KS lesions mainly involve the distal extremities, rarely involve the internal organs and the lesions are relatively benign Most patients are treated with local radiotherapy or systemic drug therapy. AIDS-KS lesions extensive, easy to affect the internal organs, the prognosis is worse than the classic KS.