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叉头框蛋白质M1(Forkhead box protein M1,FoxM1)是一种特异性的与增殖相关的转录因子。既往研究发现,FoxM1具有增强癌细胞增殖、转移和侵袭的功能,在肿瘤的发生发展中扮演着至关重要的角色。近年来研究表明,FoxM1的异常表达在乳腺癌的发生及发展中起着重要的作用,且其过表达与肿瘤患者的总生存期的关系呈负相关,为乳腺癌的早期诊断、临床预后及联合治疗提供了新的研究方向,本文就FoxM1与乳腺癌的关系做一综述。
Forkhead box protein M1 (FoxM1) is a specific proliferation-related transcription factor. Previous studies have found that FoxM1 has the function of enhancing the proliferation, metastasis and invasion of cancer cells and plays a crucial role in the development of tumors. In recent years, studies have shown that the abnormal expression of FoxM1 plays an important role in the occurrence and development of breast cancer, and its expression is negatively correlated with the overall survival of patients with cancer, which is an early diagnosis of breast cancer, clinical prognosis and Combined therapy provides a new research direction, this article reviews the relationship between FoxM1 and breast cancer.