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目的探讨急性肺栓塞(acute pulmonary embolism,APE)患者血清Apelin-13水平与死亡率的相关性。方法连续性纳入70例APE患者,根据28d死亡率情况分为存活组(n=46)和死亡组(n=24)。记录和分析治疗前Qanadli栓塞指数和血清Apelin-13水平。结果存活组患者Qanadli栓塞指数、Apelin-13水平明显低于死亡组,组间比较差异具有统计学意义(P<0.05)。Apelin-13早期诊断APE的曲线下面积(area under the curve,AUC)为0.826,cut-off值为85.1 ng/ml,敏感度为80.3%、特异度为81.2%。Apelin-13预测死亡事件的AUC为0.774,cut-off值为106.2 ng/ml,敏感度为82.1%、特异度为75.6%。Apelin-13与APE患者死亡事件(r=0.603,P<0.05)和Qanadli栓塞指数(r=0.614,P<0.05)成正相关。结论 APE患者血清Apelin-13水平明显上升,有助于早期诊断和病情预后评估。
Objective To investigate the relationship between serum Apelin-13 level and mortality in patients with acute pulmonary embolism (APE). Methods A total of 70 patients with APE were included in the study. According to the 28-day mortality, they were divided into survival group (n = 46) and death group (n = 24). The pre-treatment Qanadli embolism index and serum Apelin-13 levels were recorded and analyzed. Results Qanadli embolism index and Apelin-13 level in survivors group were significantly lower than those in death group. There was significant difference between the two groups (P <0.05). The area under the curve (AUC) for Apelin-13 early diagnosis of APE was 0.826, the cut-off value was 85.1 ng / ml, the sensitivity was 80.3% and the specificity was 81.2%. Apelin-13 predicted mortality events with AUC of 0.774, cut-off value of 106.2 ng / ml, sensitivity of 82.1% and specificity of 75.6%. Apelin-13 was positively correlated with the death of APE patients (r = 0.603, P <0.05) and Qanadli embolism index (r = 0.614, P <0.05). Conclusion The serum level of Apelin-13 in patients with APE is obviously increased, which is helpful for early diagnosis and evaluation of prognosis.