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大白鼠口服盐酸奎宁锑后,锑自胃肠道消失得很慢,八小时后;仍有约90%的锑在胃肠道存留.如先将胃与小肠间以线结扎,再使动物口服本品,肠道的锑含量仍逐渐增加.大鼠口服盐酸奎宁锑后,锑很快进入胆汁中,锑的排洩以粪为主,自尿排出者,为量极微.大白鼠口服盐酸奎宁锑24小时后,各脏器均合有锑.除胃肠外,锑的浓度以肝脏为最高,肾和脾的浓度约为肝脏的一半,而肺、心、脑和血中的锑浓度极小.可见,口服盐酸奎宁锑后锑之所以自胃肠道消失得很少,并不一定由于锑的吸收很少,部分已吸收的锑经胆管又排洩至肠道.
After oral administration of antimony, the antimony disappears from the gastrointestinal tract slowly after eight hours; about 90% of the antimony remains in the gastrointestinal tract, for example, ligating the stomach and small intestine first, Oral administration of this product, the intestinal antimony content is still gradually increased.After oral administration of antimony in rats with antimony, antimony quickly into the bile, antimony excretion to the main fecal, urinary excretion, in very small quantities. After 24 hours of antimony quinine hydrochloride, antimony was present in all organs, except for the gastrointestinal tract, the concentration of antimony was highest in the liver, and the concentration of kidney and spleen was about half that of the liver, while in the lung, heart, brain and blood The concentration of antimony is very small.It can be seen that the reason why antimony is not eliminated from the gastrointestinal tract after oral administration of quinine hydrochloride is not necessarily due to the little absorption of antimony. Some of the absorbed antimony is excreted into the intestine through the bile duct.