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先天性肾盂输尿管连接处狭窄(ureteropelvic junction obstruction,UPJO)是小儿肾积水的常见原因,约占90%。近年来,产前超声检查中发现约1 000名胎儿中就有l例肾盂输尿管连接处狭窄所导致的肾积水。早期的研究认为输尿管的蠕动纯粹是肌源性的[1],近年来随着免疫组织化学和分子生物学的广泛应用,证明输尿管内包含多种类型的神经分布,并且这些神经在输尿管蠕动中起着重要作用[2],神经分布或功能异常是导致先天性肾积水的病因之一,但导致其病变的机制尚有争论。蛋白基因产物9.5(protein
Congenital ureteropelvic junction obstruction (ureteropelvic junction obstruction, UPJO) is a common cause of hydronephrosis in children, accounting for about 90%. In recent years, prenatal ultrasound examination found that there are about 1 000 cases of hydronephrosis caused by renal pelvis and ureter junction stenosis. Earlier studies suggested ureteral peristalsis was purely muscular [1]. In recent years, with the widespread use of immunohistochemistry and molecular biology, it has been demonstrated that the ureter contains many types of nerve distribution and that these nerves are involved in ureteral peristalsis Plays an important role [2], nerve distribution or dysfunction is one of the causes of congenital hydronephrosis, but the mechanism leading to its disease is still controversial. Protein gene product