Maspin是一种抑癌基因，在多种肿瘤组织中有不同程度的表达，具有诱导细胞凋亡，抑制肿瘤细胞浸润、转移及肿瘤组织新生血管生成的作用。近年的研究多集中于 Maspin基因结构、功能及其在不同肿瘤中作用机制的探讨。 Maspin在不同肿瘤中表达趋势不完全相同，探讨其在胃肠道肿瘤中的表达及其相关机制，为分析胃肠道肿瘤的耐药机制及基因靶向治疗提供了一定的理论依据。“,”Maspin is a tumor suppressor gene,which has different degrees of expression in various tumor tissues and induces apoptosis,inhibits the formation of tumor cell invasion,metastasis and tumor angiogene-sis.In recent years,many studies focus on the structure,function and the mechanism of Maspin gene in differ-ent tumors.Some studies found Maspin expression trends are not identical in different tumors .Exploring Maspin expression in gastrointestinal cancer and its related mechanisms,will provide a theoretical basis for analyzing the mechanisms of tumor resistance and gene targeted therapy .