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现已发现两个基因(BRCA1和BRCA2)的胚系突变是卵巢癌家族中卵巢增加的主要原因,有BRCA1突变的妇女发生卵巢癌的危险性增加20％～40％,有BRCA2突变的妇女约为15％～25％。有BRCA突变的妇女应该在生育期进行预防性卵巢切除(PO)。
It has been found that the germline mutations of two genes (BRCA1 and BRCA2) are the major cause of ovarian cancer in ovarian cancer families. The risk of ovarian cancer in women with BRCA1 mutation increased by 20% -40%. Women with BRCA2 mutation 15% ~ 25%. Women with BRCA mutations should have prophylactic ovariectomy (PO) during their reproductive years.