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作者过去曾注意到流行性出血热尸检病例脑内脂褐素似有增多现象,本研究的目的是通过尸检典型病例以及乳鼠实验来观察流行性出血热时脑内脂褐素有无增加.从尸检病例脑组织各取10个组织块.切片经苏丹Ⅳ及苏丹黑染色,与对照组切片中脂褐素含量进行比较.将流行性出血热病毒感染BALB/c乳鼠与对照组脑组织脂褐素含量比较,证明流行性出血热感染时脑组织中脂褐素沉积确有明显增加.鉴于脂褐素增加可见于发热期,感染显然是促其形成的因素.但低血压及休克是否发挥作用,也不能排除。
In the past, the authors had noticed that there was an increase in lipofuscin in the brain of autopsy cases with epidemic hemorrhagic fever. The purpose of this study was to observe the presence or absence of lipofuscin in epileptic hemorrhagic fever in typical cases of necropsies and in suckling mice. From the autopsy cases, 10 tissue blocks were taken from the brain tissue. The sections were stained by Sudan IV and Sudan black and compared with the lipofuscin content in the control group. The epidemic hemorrhagic fever virus was infected into BALB/c suckling mice and the control brain tissue. The comparison of lipofuscin content proves that lipofuscin deposition in brain tissue does increase significantly with epidemic hemorrhagic fever infection. In view of the increase in lipofuscin seen in the febrile phase, infection is obviously a factor that promotes its formation. However, hypotension and shock are It cannot be ruled out to play a role.