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目的 了解婴儿肝炎综合征 (简称婴肝 )患儿的肝脏病理改变。方法 对 16例婴肝患儿肝穿刺活检 ,并与临床诊断比较。结果 病理及临床所示肝硬化符合率较高 ,以乙肝病毒感染为主 ,共 11例。肝脏病理结果自肝细胞肿胀、点状坏死 ,直至纤维结缔组织增生均可见到 ,并观察到 1例患儿 4年后再次复查肝穿刺检查 ,已由慢性活动性肝炎 (CAH)转为慢性迁延性肝炎 (CPH)。结论 肝穿刺病理检查为小儿肝脏疾病不可缺少的诊治手段 ,应当大力提倡。
Objective To understand the pathological changes of liver in infantile hepatitis syndrome (infant liver). Methods Sixteen children with liver biopsy were compared with the clinical diagnosis. Results The pathology and clinical evidence showed that the coincidence rate of cirrhosis was high, with hepatitis B virus infection as the main part, a total of 11 cases. Liver pathology results from hepatocellular swelling and punctate necrosis until fibrous connective tissue hyperplasia can be seen and one child is observed again after 4 years liver biopsy has been chronic active hepatitis (CAH) to chronic persistent Hepatitis (CPH). Conclusion The pathological examination of liver biopsy is an indispensable means of diagnosis and treatment of pediatric liver disease and should be strongly advocated.