AIM:To investigate the dynamic changes of capillarizationand ped-sinusoid fibrosis in an alcoholic liver disease modelinduced by a new method.METHODS:Male SD rats were randomly divided into 6groups,namely normal,4 d,2 w,4 w,9 w and 11 w groups.The animals were fed with a mixture of alcohol for designateddays and then decollated,and their livers were harvestedto examine the pathological changes of hepatocytes,hepaticstellate cells,sinusoidal endothelial cells,sinusoid,peri-sinusoid.The generation of three kinds of extra cellular matrixwas also observed.RESULTS:The injury of hepatocytes became severer asmodeling going on.Under electronic microscope,fattyvesicles and swollen mitochondria in hepatocytes,activatedhepatic stellate cells with fibrils could been seen near oraround it.Fenestrae of sinusoidal endothelial cells weredecreased or disappeared,sinusoidal basement was formed.Under light microscopy typical peri-sinusoid fibrosis,gridding-like fibrosis,broaden portal areas,hepatocyte’s fatty andballoon denaturation,iron sediment,dot necrosis,congregated lymphatic cells and leukocytes were observed.Type Ⅰ collagen showed an increasing trend as modelinggoing on,slightly recovered when modeling stopped for 2weeks.Meanwhile,type Ⅳ collagen decreased rapidly whenmodeling began and recovered after modeling stopped for2 weeks.Laminin increased as soon as modeling began anddid not recover when modeling stopped for 2 weeks.CONCLUSION:The pathological changes of the modelwere similar to that of human ALD,but mild in degree.Ithad typical peri-sinusoid fibrosis,however,capillarizationseemed to be instable.It may be related with the reductionof type Ⅳ collagen in the basement of sinusoid duringmodeling. AIM: To investigate the dynamic changes of capillarization and ped-sinusoid fibrosis in an alcoholic liver disease model induced by a new method. METHODS: Male SD rats were randomly divided into 6 groups, namely normal, 4 d, 2 w, 4 w, 9 w and 11 w groups. The animals were fed with a mixture of alcohol for designated days and then decollated, and their livers were harvestedto examine the pathological changes of hepatocytes, hepaticstellate cells, sinusoidal endothelial cells, sinusoids, peri-sinusoid. The generation of three kinds of extra cellular matrixwas also observed .RESULTS: The injury of hepatocytes became severer asmodeling going on .Under electronic microscopes, fattyvesicles and swollen mitochondria in hepatocytes, activatedhepatic stellate cells with fibrils could have seen near oraround it.Fenestrae of sinusoidal endothelial cells were created or disappeared, sinusoidal basement was formed. Undead light microscopy typical peri-sinusoid fibrosis, gridding-like fibrosis, broaden portal areas, hepatocyte’s fatty andballoon denaturation, iron sediment, dot necrosis, congregated lymphatic cells and leukocytes were observed.Type Ⅰ collagen showed an increasing trend as modegoing on, slightly recovered when modeling stopped for 2 weeks. stopped for 2 weeks. Laminin increased as soon as modeling began anddid not recover when modeling stopped for 2 weeks.CONCLUSION: The pathological changes of the modelwere similar to that of human ALD, but mild in degree. Ithad typical peri-sinusoid fibrosis, however, capillarizationseemed to be instable. It may be related with the reductionof type Ⅳ collagen in the basement of sinusoid duringmodeling.