手术和麻醉对肝脏均有不利的影响,但大多数较轻并迅速恢复,此影响常与手术广泛性有关;肝病患者术后可能出现严重肝功能紊乱,甚至出现急性肝功能衰竭.由于有功能的肝细胞在数量上的减少,对内源性化合物和输入的外源性药物的代谢能力减退,改变了麻醉药的药效作用及作用持续时间。本文的重点在于阐述麻醉对肝脏的影响和肝病患者的麻醉问题. Surgery and anesthesia have adverse effects on the liver, but most of them are mild and rapid recovery, the impact is often associated with extensive surgery; patients with liver disease may have severe liver dysfunction, and even acute liver failure due to functional The decrease in the number of hepatocytes, the diminished ability of the endogenous compounds and the imported exogenous drugs to alter the pharmacodynamic effects and duration of action of the anesthetics. This article focuses on explaining the effects of anesthesia on the liver and the anesthesia in patients with liver disease.