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子宫颈癌是常见的妇科恶性肿瘤，从分子水平研究其病因学起来越受到关注。原癌基因c-fos编码一种核磷蛋白，能与c－jnn原癌基因产物结合形成复合物，调节基因转录。本实验对40例宫颈癌中C－fos蛋白的表达与肿瘤组织分化程度、临床分期及预后进行了研究，并与正常宫颈（2例）、慢性宫颈炎（2例）进行对照。结果表明：C－fos在宫颈癌中阳性表达率为70％（28／40），在正常宫颈与慢性宫颈炎中不表达（0／4）。c－fos与肿瘤组织分化程度、临床分期无关，与预后有关。提示c－fos蛋白有可能成为判断宫颈癌预后的指标之一。
Cervical cancer is a common gynecological malignancy, the molecular level from the etiology of the more attention. Proto-oncogene c-fos encodes a nuclear phosphoprotein that binds to the c-jnn protooncogene to form a complex that regulates gene transcription. In this study, 40 cases of cervical cancer C-fos protein expression and tumor differentiation, clinical stage and prognosis were studied, and normal cervix (2 cases), chronic cervicitis (2 cases) were compared. The results showed that the positive rate of C-fos in cervical cancer was 70% (28/40), but not in normal cervix and chronic cervicitis (0/4). c-fos and tumor tissue differentiation, clinical stage has nothing to do with the prognosis. Tip c-fos protein may become one of the indicators to determine the prognosis of cervical cancer.