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研究发现,脑缺血时诱导了包括c-fos原癌基因在内的多种原癌基因家族的表达。c-fos原癌基因即为c-fos原癌基因家族中的一种,它和表达产物c-fos蛋白在神经元活动时表达活跃,被广泛用作神经元功能的标志物,是目前研究得最多的原癌基因之一。本文就c-fos原癌基因与脑缺血关系研究进展作一综述。 1 c-fos原癌基因及fos蛋白概述 1.1 c-fos原癌基因 c-fos原癌基因的研究始于二十世纪八十年代中后期,属于即刻早期基因
The study found that the expression of multiple oncogene families, including the c-fos protooncogene, was induced during cerebral ischemia. The c-fos proto-oncogene is one of the c-fos proto-oncogene families. Its c-fos protein is active in neuronal activity and is widely used as a marker of neuronal function. It is the current study One of the most proto-oncogenes. This article reviews the progress of the relationship between c-fos protooncogene and cerebral ischemia. 1 c-fos proto-oncogene and fos protein overview 1.1 c-fos proto-oncogene proto-oncogene c-fos gene research began in the mid and late 1980s, belong to immediate early gene