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目的探讨多巴胺联合美托洛尔治疗小儿肺炎合并心力衰竭临床效果,为临床诊治提供参考。方法选择2012年1月-2014年1月肺炎合并心力衰竭患儿,按照数字表法随机分为观察组与对照组,每组各40例。对照组常规抗感染等综合治疗,观察组在对照组基础上联合美托洛尔及多巴胺治疗。对比两组患者治疗有效率、体征改善时间、临床症状以及心肌酶水平。结果观察组治疗有效率为95.00%,对照组为80.00%,两组比较,差异有统计学意义(χ~2=5.621,P=0.008);观察组啰音消失、喘息消失、心率平稳、肝脏回缩时间与对照比较,差异有统计学意义(t=5.227、6.114、5.421、6.324,P=0.009、0.004、0.008、0.003);观察组呼吸、心率、血氧饱和度改善均优于对照组(P<0.05);观察组CK-MB、LDH改善均优于对照组(P<0.05)。结论多巴胺联合美托洛尔治疗小儿肺炎合并心力衰竭临床效果佳,利于改善心肌功能,值得临床推广应用。
Objective To investigate the clinical effect of dopamine combined with metoprolol in the treatment of children pneumonia complicated with heart failure and to provide reference for clinical diagnosis and treatment. Methods From January 2012 to January 2014, children with pneumonia complicated with heart failure were randomly divided into observation group and control group according to digital table method, 40 cases in each group. Control group conventional anti-infection and other comprehensive treatment, the observation group on the basis of the control group metoprolol and dopamine treatment. Comparison of two groups of patients treatment efficiency, signs of improvement, clinical symptoms and myocardial enzyme levels. Results The effective rate was 95.00% in the observation group and 80.00% in the control group. There was significant difference between the two groups (χ ~ 2 = 5.621, P = 0.008); the rales of the observation group disappeared, wheezing disappeared, the heart rate was stable, (T = 5.227,6.114,5.421,6.324, P = 0.009,0.004,0.008,0.003). The improvement of respiration, heart rate and oxygen saturation in the observation group were better than those in the control group (P <0.05). The improvement of CK-MB and LDH in observation group was better than that in control group (P <0.05). Conclusion The combination of dopamine and metoprolol in the treatment of children with pneumonia complicated with heart failure has a good clinical effect, which is beneficial to improve myocardial function and is worthy of clinical application.