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囊胚来源的胚胎干细胞(embryonic stem cells,ESCs)和性腺来源的胚胎生殖细胞(embryonic germ cells,EGCs)代表了多能干细胞系的两个经典类型,但它们的分子等价性仍未被完全了解。Choi等对遗传背景相同的ESCs和EGCs细胞系之间的全基因组甲基化模式进行比较,从而确定它们表观遗传的相似性和差异性。令人惊讶的是,他们发现真正驱动ESCs和EGCs甲基化模式的是性别而非细胞类型。细胞融合实验进一步表明,X染色体与常染色体的比值决定了甲基化水平,雌性杂交细
Blastocyst derived embryonic stem cells (ESCs) and gonadal derived embryonic germ cells (EGCs) represent the two classic types of pluripotent stem cell lines, but their molecular equivalence has not yet been completely To understanding. Choi et al. Compared genome-wide methylation patterns between ESCs of the same genetic background and EGC cell lines to determine their epigenetic similarities and differences. Surprisingly, they found that genders, rather than cell types, actually drive the methylation patterns of ESCs and EGCs. Cell fusion experiments further show that, X chromosome and autosomal ratio determines the level of methylation, female hybrid fine