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肿瘤的恶性转化与端粒酶(Telomerase)的激活有关,而正常体细胞与绝大部分良性肿瘤缺乏端粒酶活性.研究证实端粒酶表达与大肠癌的发生有密切关系.目前,端粒及端粒酶已被广泛认为是新的肿瘤标记物以及抗肿瘤治疗的靶点.端粒酶抑制剂的研究受到人们的关注,而针对端粒酶的治疗有着潜在的临床应用前景.全反式维甲酸(all-transretinoic acid,RA)是迄今研究最多的分化诱导剂之一,可以诱导多种肿瘤细胞分化逆转其恶性表型.为了了解实体瘤细胞恶性表型逆转是否与端粒酶活性抑制相关,本文观察了
Malignant transformation of tumors is related to the activation of telomerase (Telomerase), and normal somatic cells and most benign tumors lack telomerase activity. Studies have confirmed that telomerase expression is closely related to the occurrence of colorectal cancer. Currently, telomeres Telomerase has been widely regarded as a new tumor marker and a target for anti-tumor therapy. The study of telomerase inhibitors has attracted people’s attention, and the treatment of telomerase has potential clinical application prospects. Retinoic acid (RA) is one of the most studied differentiation inducers so far, and can induce differentiation of various tumor cells to reverse its malignant phenotype. In order to understand whether the malignant phenotype reversal of solid tumor cells and telomerase activity Inhibition related, this article observed