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近几年来,有许多人报告抗氧化剂在先于或与致癌剂同时给予实验动物时有抑制化学致癌作用的功能。本文作者报告了无害的天然抗氧化剂——还原型谷胱甘肽能使黄曲霉毒素B_1(AFB_1)诱发的肝细胞癌消退。作者用体重100克Wistar雌性大鼠进行试验,实验组动物每次灌胃25/μg AFB_1(溶于2.5 μl二甲基甲酰胺[DMF]),每周灌胃5次,连续8周。对照组动物只给予DMF 2.5 μl。在每次灌胃之前将两种溶液都用蒸馏水
In recent years, many people report that antioxidants have the function of inhibiting chemical carcinogenesis when they are given to experimental animals prior to or simultaneously with a carcinogen. The authors report that the innocuous, natural antioxidant, reduced glutathione, regresses hepatocellular carcinoma induced by aflatoxin B_1 (AFB_1). The authors used 100g Wistar female rats to test. The animals in the experimental group were orally gavaged with 25μg / mL AFB_1 (dissolved in 2.5μl dimethyl formamide [DMF]) once a week for 5 weeks for 8 weeks. Control animals were given only 2.5 μl of DMF. Both solutions were distilled water before each gavage