论文部分内容阅读
复方诺氟沙星滴耳液由诺氟沙星、甲硝唑、地塞米松磷酸钠等成分组成。用于治疗急慢性化脓性中耳炎。有关测定制剂中甲硝唑和氟哌酸的含量已有文献报道[1],我们采用梯度洗脱的方法,以醋酸氢化可的松为内标,同时测定滴耳液中诺氟沙星、甲硝唑和地塞米松磷酸钠的含量,该方法简便、快速、准确、重现性好。1 仪器与试药 HP-1100液相色谱仪,VWD紫外检测器;PHS-3C型酸度计（上海）;PU-8800型紫外分光光度计（英国）;诺氟沙星对照品纯度99.1％,甲硝唑对照品纯度99.6％,地塞米松磷酸钠对照品纯度99.5％,醋酸氢化可的松纯度99.6％（均为
Compound norfloxacin ear drops from norfloxacin, metronidazole, dexamethasone sodium phosphate and other ingredients. For the treatment of acute and chronic suppurative otitis media. The determination of metronidazole and norfloxacin in the preparation of the content has been reported in the literature [1], we use a gradient elution method to hydrocortisone acetate as an internal standard, simultaneous determination of norfloxacin ear drops, Metronidazole and dexamethasone sodium phosphate content, the method is simple, fast, accurate, reproducible. 1 instrument and reagent HP-1100 liquid chromatography, VWD UV detector PHS-3C pH meter (Shanghai); PU-8800 UV spectrophotometer (UK) Norfloxacin reference purity of 99.1% The purity of metronidazole reference substance was 99.6%, the purity of dexamethasone sodium phosphate reference substance was 99.5% and the purity of hydrocortisone acetate was 99.6% (both